Decode With Confidence
AI-powered clarity for every variant. Smarter analysis. Better patient outcomes.
AI Agent
Vicuña
Your genomics copilot
A conversational AI agent purpose-built for variant analysis. Vicuña guides clinicians through complex genomic data with natural language, integrating clinical evidence and the latest literature.
- ✓ Evidence-driven, guideline-compliant classification
Aggregates clinical evidence from ClinVar, gnomAD, literature, and functional data — aligned with ACMG/AMP guidelines. - ✓ Integrated tool & database access
Query annotation sources, external databases, and specialized analysis tools directly within the conversation. - ✓ Human-in-the-loop case summarization
Distill complex multi-variant cases into structured clinical summaries ready for review — with clinician oversight at every step.
Vicuña Assistant
What is the clinical significance of BRCA2 c.5946delT?
BRCA2 c.5946delT (p.Ser1982ArgfsTer22) is classified as **Pathogenic** by ClinVar. This frameshift variant in exon 11 disrupts the DNA repair domain. Associated with hereditary breast-ovarian cancer syndrome. 47 submitters support this classification.
Show me the ACMG criteria breakdown.
From dialogue to diagnosis.
Built AI-native from the ground up.
Platform
Noxia
VCF to signed-out report.
Noxia is a clinical-grade variant analysis platform that transforms raw VCF files into regulatory-ready clinical reports.
Upload
Import VCF files directly or via LIMS integration
Annotate & Classify
AI-powered ACMG/AMP classification with evidence aggregation
Review & Collaborate
Team-based review with comments, assignments, and role-based access
Sign-Out & Report
PDF generation with full audit trail
Case WES-2024-0847
18 variants · 3 in Review
| Variant | Gene | Classification | Status |
|---|---|---|---|
| chr17:7674220 C>T | TP53 | Pathogenic | Reviewed |
| chr2:47702181 G>A | MSH2 | Likely Pathogenic | Pending |
| chr7:55249071 T>G | EGFR | VUS | Pending |
| chr13:32929387 A>C | BRCA2 | Benign | Reviewed |
Agentic AI, harnessed by clinicians.
Dashboard
Case WES-2024-0847
18 variants · 3 in Review
| Gene | Classification |
|---|---|
| TP53 | Pathogenic |
| MSH2 ⚠ | Unclassified |
| BRCA2 | Benign |
MSH2 c.942+3A>T
MSH2 c.942+3A>T
Report — WES-2024-0847
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Decode with confidence.
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